Supplement References and Research Resources 2018-03-08T05:48:39+00:00

Transformation Skin Creme

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Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters.

Topical delivery of acetyl hexapeptide-8 from different emulsions: influence of emulsion composition and internal structure.

In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation.

The study of cellular cytotoxicity of argireline – an anti-aging peptide.

The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects.

The anti-wrinkle efficacy of Argireline.

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.

Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Preparation and stability of cosmetic formulations with an anti-aging peptide.


Protective effect of geranylgeranylacetone against radiation-induced delayed effects on human keratinocytes.

Hormesis-Based Anti-Aging Products: A Case Study of a Novel Cosmetic.

Treatment with Geranylgeranylacetone Induces Heat Shock Protein 70 and Attenuates Neonatal Hyperoxic Lung Injury in a Model of Bronchopulmonary Dysplasia.

Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling.

Geranylgeranylacetone inhibits melanin synthesis via ERK activation in Mel-Ab cells.

Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.

Topical use of teprenone

United States Patent Application 20090214607 (August 27, 2009)

Skin whitening composition containing teprenone
European Patent Application 0561305 A1 (September 22, 1993)


Enriched Astaxanthin Extract from Haematococcus pluvialis Augments Growth Factor Secretions to Increase Cell Proliferation and Induces MMP1 Degradation to Enhance Collagen Production in Human Dermal Fibroblasts.

Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage.

Effect of astaxanthin on cutaneous wound healing.

Protective effects of astaxanthin on skin deterioration.

A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging.

The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts.

Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation.


Biological importance and applications of squalene and squalane.

Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics.

Plant stem cells

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation.

Plant stem cells as innovation in cosmetics.

Overview of plant stem cells in cosmeceuticals.

Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution.

Mega-Nutrition Organic Superfood

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Cocoa and Chocolate in Human Health and Disease

Nutrition Facts for Cocoa and Chocolate

Impact of Cocoa Consumption on Inflammation Processes—A Critical Review of Randomized Controlled Trials

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

The cardiovascular benefits of dark chocolate.


Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men

Açai (Euterpe oleracea Mart.) pulp dietary intake improves cellular antioxidant enzymes and biomarkers of serum in healthy women

Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities

Absorption and biological activity of phytochemical-rich extracts from açai (Euterpe oleracea Mart.) pulp and oil in vitro


Antioxidant and Associated Capacities of Camu Camu (Myrciaria dubia): A Systematic Review

Ellagic acid derivatives, ellagitannins, proanthocyanidins and other phenolics, vitamin C and antioxidant capacity of two powder products from camu-camu fruit (Myrciaria dubia)

Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties

Nutritional composition and vitamin C stability in stored camu-camu (Myrciaria dubia) pulp


Chlorella: A Nutrient-Rich Algae

Therapeutic potentials of unicellular green alga Chlorella in advanced glycation end product (AGE)-related disorders

Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers


Goji Berry Benefits: Antioxidant & Anti-Inflammatory Superfruit

Goji berries, dried

Goji Berry 


Health Benefits of Moringa oleifera (PubMed abstract) (full article)

Moringa Oleifera leaf extract increases plasma antioxidant status associated with reduced plasma malondialdehyde concentration without hypoglycemia in fasting healthy volunteers

Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview


Spirulina in Clinical Practice: Evidence-Based Human Applications – NASA

Anti-Inflammatory Effects of Spirulina platensis Extract via the Modulation of Histone Deacetylases

A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men


The Medical Use of Wheatgrass: Review of the Gap Between Basic and Clinical Applications

Evaluation of the antioxidant activity of wheatgrass (Triticum aestivum L.) as a function of growth under different conditions

“Helps support a healthy immune system”


Effects of cocoa on the immune system:

Anti-influenza virus effects of cocoa

Cocoa-enriched diets modulate intestinal and systemic humoral immune response in young adult rats

Cocoa: antioxidant and immunomodulator

Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells

Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line

Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro


Antioxidant and Associated Capacities of Camu Camu (Myrciaria dubia): A Systematic Review

Nutritional compositions and health promoting phytochemicals of camu-camu (myrciaria dubia) fruit: A review

Active compounds and medicinal properties of Myrciaria genus


Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of Natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)

Anti-inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum

A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation

Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice

Oral administration of Chlorella vulgaris augments concomitant antitumor immunity


Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects

Immune activities comparison of polysaccharide and polysaccharide-protein complex from Lycium barbarum L.

The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo

Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells


Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in animals

Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in Wistar albino rats

Some newer marker phytoconstituents in methanolic extract of Moringa oleifera leaves and evaluation of its immunomodulatory and splenocytes proliferation potential in rats


Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and Ecofriendly Spirulina

Impact of daily supplementation of Spirulina platensis on the immune system of naïve HIV-1 patients in Cameroon: a 12-months single blind, randomized, multicenter trial

The effects of Spirulina on anemia and immune function in senior citizens

Spirulina in Clinical Practice: Evidence-Based Human Applications


The Immunologically Active Oligosaccharides Isolated from Wheatgrass Modulate Monocytes via Toll-like Receptor-2 Signaling

“Energizes the body to feel years younger”


Food of the Gods: Cure for Humanity? A Cultural History of the Medicinal and Ritual Use of Chocolate

Cocoa confers life span extension in Drosophila melanogaster.


Açai Palm Fruit (Euterpe oleracea Mart.) Pulp Improves Survival of Flies on a High Fat Diet

A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies


Antioxidant and Associated Capacities of Camu Camu (Myrciaria dubia): A Systematic Review


An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides


A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)

Lycium barbarum Polysaccharides Protect Human Lens Epithelial Cells against Oxidative Stress–Induced Apoptosis and Senescence


The effects of Spirulina on anemia and immune function in senior citizens

Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?


Wheat Seedlings as Food Supplement to Combat Free Radicals: An In Vitro Approach

Quantum Heart Max

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Amla, or Wild Indian Gooseberry

Analgesic Effect of Indian Gooseberry (Emblica officinalis Fruit) Extracts on Postoperative and Neuropathic Pain in Rats.

Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1beta/miR-101/Lin28B Signaling Pathway. 

Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms.

Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation.

Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation.

The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in rat.

Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder.

Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients.

Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process.

Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.

Flavonoids from Emblica officinalis and Mangifera indica-effectiveness for dyslipidemia.

Coleus Forskohlii

Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii.

Forskolin: from an ayurvedic remedy to a modern agent.

Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives.

The positive inotropic-acting forskolin, a potent adenylate cyclase activator.

Reishi Mushrooms

Cardioprotective Activity of Ganoderma lucidum Extract during Total Ischemia and Reperfusion of Isolated Heart.

Effect of Ganoderma lucidum polysaccharides on hemodynamic and antioxidation in T2DM rats.

Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat.

Ganoderma lucidum extract in cardiac diastolic dysfunction and irreversible cardiomyocytic damage in ischemia and reperfusion of the isolated heart.

Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity.

Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.

Grape Skin Extract

Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells.

Resveratrol Protects Against Pulmonary Arterial Hypertension in Rats via Activation of Silent Information Regulator 1.

Antioxidant capacity of trans-resveratrol dietary supplements alone or combined with the mycotoxin beauvericin.

Cardiovascular Protective Effects and Clinical Applications of Resveratrol.

Polyphenols in preventing endothelial dysfunction.

Resveratrol and anti-atherogenic effects.

A study on the effect of resveratrol on lipid metabolism in hyperlipidemic mice.

Resveratrol, wine, and atherosclerosis.

Resveratrol in cholesterol metabolism and atherosclerosis.

“Cordyceps” (Ophiocordyceps sinensis; formerly Cordyceps Sinensis)

Cultured Mycelium Cordyceps sinensis allevi¬ates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells.

Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells.

Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

The extract of Cordyceps sinensis inhibited airway inflammation by blocking NF-kappaB activity.

Anti-inflammation effects of Cordyceps sinensis mycelium in focal cerebral ischemic injury rats.

Lion’s Mane

A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced by H2O2 in human gastric mucosa epithelium cell.

Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review.

Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.

The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages.

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds.

Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms.

Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.

Anti-inflammatory activity of mycelial extracts from medicinal mushrooms.

Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals.

Hericium erinaceus: an edible mushroom with medicinal values.

Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides.

A beta-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformation.

Maitake Mushrooms

Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review.

A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.

Inhibitory potential of Grifola frondosa bioactive fractions on alpha-amylase and alpha-glucosidase for management of hyperglycemia.

MT-alpha-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic beta-cells.

Inhibitory effects of medicinal mushrooms on ?-amylase and ?-glucosidase – enzymes related to hyperglycemia.

Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake).

Hypoglycemic activity of Grifola frondosa rich in vanadium.

Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.

Preparation of a chemically sulfated polysaccharide derived from Grifola frondosa and its potential biological activities.

Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats.

Maitake extracts and their therapeutic potential.

Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I.

Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats.


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Sake Lees

Black rice (Oryza sativa L. var. japonica) hydrolyzed peptides induce expression of hyaluronan synthase 2 gene in HaCaT keratinocytes.

Quantitation and structural determination of glucosylceramides contained in sake lees.

Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.

Effects of ethyl alpha-D-glucoside on skin barrier disruption.

Effect of ingested concentrate and components of sake on epidermal permeability barrier disruption by UVB irradiation.

Effects of ethyl-alpha-d-glucoside on human dermal fibroblasts.

Effect of a sake concentrate on the epidermis of aged mice and confirmation of ethyl alpha-D-glucoside as its active component.

Radish root

A Novel Compound Rasatiol Isolated from Raphanus sativus Has a Potential to Enhance Extracellular Matrix Synthesis in Dermal Fibroblasts

Vitamins and Skin Health

Topical Retinol Restores Type I Collagen Production in Photoaged Forearm Skin within Four Weeks.

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.

Vitamin E in dermatology.

Vitamin E: critical review of its current use in cosmetic and clinical dermatology.

Interaction of vitamins C and E as better cosmeceuticals.

Comparative effects of biodynes, tocotrienol-rich fraction, and tocopherol in enhancing collagen synthesis and inhibiting collagen degradation in stress-induced premature senescence model of human diploid fibroblasts.

Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts.

Induction of collagen synthesis by ascorbic acid. A possible mechanism.


The role of hyaluronan in wound healing.

Molecular insights into the effects of sodium hyaluronate preparations in keratinocytes.

The use of sodium hyaluronate for the treatment of radiation recall dermatitis.

Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism.

Proposed mechanisms of action for retinoid derivatives in the treatment of skin aging.

Effect of hyaluronate on physicochemical and biological properties of collagen solution which could be used as collagen filler.

Recipes for reconstituting skin.

Collagen-based wound dressing: effects of hyaluronic acid and fibronectin on wound healing.


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Fucoidan (not restricted to Undaria pinnatifida or Laminaria japonica)

Therapies from Fucoidan; Multifunctional Marine Polymers.

The sulfated polysaccharide fucoidan rescues senescence of endothelial colony-forming cells for ischemic repair.

Therapeutic effect of fucoidan-stimulated endothelial colony-forming cells in peripheral ischemia.

Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus.

L-Arginine HCL

Pharmacogenetic influence of eNOS gene variant on endothelial and glucose metabolism responses to L-arginine supplementation: Post hoc analysis of the L-arginine trial.

Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypertension and hyperhomocysteinemia – a randomized, double-blind, placebo-controlled, cross-over trial.

Improvement of the physical performance is associated with activation of NO/PGC-1alpha/mtTFA signaling pathway and increased protein expressions of electron transport chain in gastrocnemius muscle from rats supplemented with L-arginine.

Mitochondrial dysfunction in brain cortex mitochondria of STZ-diabetic rats: effect of l-Arginine.

l-Arginine supplementation improves rats’ antioxidant system and exercise performance.

The effect of l-arginine supplementation on body composition and performance in male athletes: a double-blinded randomized clinical trial.

Therapeutic Benefits of l-Arginine: An Umbrella Review of Meta-analyses.

L-arginine supplementation and risk factors of cardiovascular diseases in healthy men: a double-blind randomized clinical trial.


Therapeutic benefits of glutamine: An umbrella review of meta-analyses.

The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise.

Effect of L-glutamine supplementation on electromyographic activity of the quadriceps muscle injured by eccentric exercise.

Glutamine metabolism in advanced age.

Effects of 6-month supplementation with beta-hydroxy-beta-methylbutyrate, glutamine and arginine on vascular endothelial function of older adults.


Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice.

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.

The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run.

Absorption of triglycine, diglycine, glycine or equimolar mixtures of diglycine and glycine in the perfused small intestine of rats.

Creatine Deficiency Syndromes.


Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women.

Food restriction and lysine supplementation alter growth, RNA, DNA, and protein contents of skeletal muscle.

Utility of fasting essential amino acid plasma levels in formulation of nutritionally adequate diets III: lowering of rat serum cholesterol levels by lysine supplementation.

Effect of arginine:lysine and glycine:methionine intake ratios on dyslipidemia and selected biomarkers implicated in cardiovascular disease: A study with hypercholesterolemic rats.

Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure?


Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.

L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism.

Effect of arginine, ornithine and citrulline supplementation upon performance and metabolism of trained rats.

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise.

Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.

Reishi Mushrooms

Activating mitochondrial regulator PGC-1alpha expression by astrocytic NGF is a therapeutic strategy for Huntington’s disease.

Triterpenoids with neurotrophic activity from Ganoderma lucidum.

The signaling cascades of Ganoderma lucidum extracts in stimulating non-amyloidogenic protein secretion in human neuroblastoma SH-SY5Y cell lines.

Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells.

Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism.

Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.

Ganoderma lucidum and its pharmaceutically active compounds.


Neuropharmacological Properties of Withania somnifera – Indian Ginseng: An Overview on Experimental Evidence with Emphasis on Clinical Trials and Patents.

Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells.

Effect of Withania somnifera Dunal Root Extract on Behavioral Despair Model in Mice: a Possible Role for Nitric Oxide.

Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke.

Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis.

Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities.

Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity.

Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.

Antioxidant activity of glycowithanolides from Withania somnifera.

Goji Berries

Lycium barbarum polysaccharide attenuates type II collagen-induced arthritis in mice.

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides.

An Evidence-Based Systematic Review of Goji (Lycium spp.) by the Natural Standard Research Collaboration.

Effect of Goji (Lycium barbarum) on expression of genes related to cell survival.

Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity.

Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults.

A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi.


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Vitamins and Minerals

The role of vitamins and minerals in energy metabolism and well-being.

Vitamin A.

Vitamin C.

Vitamin D.

Vitamin E.

Vitamin B-1 (Thiamin).

Vitamin B-2 (Riboflavin).

Vitamin B-6.

Vitamin B-12.

Folic Acid.

Pantothenic Acid.



Digestive Enzyme Supplementation

The role of enzyme supplementation in digestive disorders.

Digestive Enzyme Supplementation in Gastrointestinal Diseases.

Can the supplementation of a digestive enzyme complex offer a solution for common digestive problems?

Lactobacillus acidophilus

Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial.

Effect of Lactobacillus acidophilus and Bifidobacterium bifidum supplementation to standard triple therapy on Helicobacter pylori eradication and dynamic changes in intestinal flora.

Lactobacillus acidophilus supplementation in human subjects and their resistance to enterotoxigenic Escherichia coli infection.

Effect of dietary inclusion of Lactobacillus acidophilus ATCC 43121 on cholesterol metabolism in rats.

Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yogurt matrix.

Fructooligosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy humans.

Impact of Lactobacillus acidophilus on the normal intestinal microflora after administration of two antimicrobial agents.

Minor Ingredients

Time- and dose-dependent effect of psyllium on serum lipids in mild-to-moderate hypercholesterolemia: a meta-analysis of controlled clinical trials.

Microalgae Nutraceuticals.

Echinacea purpurea: Pharmacology, phytochemistry and analysis methods.

Chronic Inflammatory Diseases and Green Tea Polyphenols.

Chronic ingestion of apple pectin can enhance the absorption of quercetin.

Effects of orange and apple pectin on cholesterol concentration in serum, liver and faeces.

Effects of kelp supplementation on thyroid function in euthyroid subjects.


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“Curcumin helps activate more than 700 genes…”

Effects of curcumin on the gene expression profile of L-02 cells.

Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines.

“Thousands of research studies have been done on the health benefits of curcumin”

See PubMed search on curcumin 10,000+ articles):

“…increase bioavailability or the amount that is absorbed by the body…” (this ref. may apply)

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.

“Fight inflammation…”

Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases

Epigenetic regulation of high glucose-induced proinflammatory cytokine productionin monocytes by curcumin

Antioxidant and anti-inflammatory properties of curcumin.

“Strengthen immunity”

Immune Modulation by Curcumin: The Role of Interleukin-10.

Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway.

Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection.

Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes.

Immunomodulation by curcumin.

“Promotes overall better health”

Curcumin: From ancient medicine to current clinical trials

Pharmacology of Curcuma longa.

Curcumin: the Indian solid gold.

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.

Curcumin and Health.

“Support cardiovascular health”

The Emerging Role of Curcumin for Improving Vascular Dysfunction: A Review.

Curcumin as a potential protective compound against cardiac diseases.

Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms.

Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity.

Curcumin Exerts its Anti-hypertensive Effect by Down-regulating the AT1 Receptor in Vascular Smooth Muscle Cells.

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro.

“Boost your weight loss efforts”

Phytochemicals in regulating fatty acid beta-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss.

Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study.

Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way.

Curcumin and obesity.

“Helps stimulate digestive juices and metabolize food”

Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats.

Effects of various food ingredients on gall bladder emptying

Fat digestion and absorption in spice-pretreated rats.

In vitro influence of spices and spice-active principles on digestive enzymes of rat pancreas and small intestine.

Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats.


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Black radish

Contractile effect of radish and betel nut extracts on rabbit gallbladder.

Antioxidant and choleretic properties of Raphanus sativus L. sprout (Kaiware Daikon) extract.

Antioxidant effect of squeezed juice from black radish (Raphanus sativus L. var niger) in alimentary hyperlipidaemia in rats.

Effects of semi-purified dietary fibers isolated from Lagenaria siceraria, Raphanus sativus and Lentinus edodes on fecal steroid excretions in rats.

Raphanus sativus L. var niger as a source of phytochemicals for the prevention of cholesterol gallstones.

Antilithiasic and hypolipidaemic effects of Raphanus sativus L. var. niger on mice fed with a lithogenic diet.

Raphanus sativus extract prevents and ameliorates zearalenone-induced peroxidative hepatic damage in Balb/c mice.

Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity.

Protective role of Raphanus sativus root extract on paracetamol-induced hepatotoxicity in albino rats.

Deoxycholic acid

Specific bile acids inhibit hepatic fatty acid uptake in mice.

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

Artichoke extract

The hepatocurative effects of Cynara scolymus L. leaf extract on carbon tetrachloride-induced oxidative stress and hepatic injury in rats.

Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.

Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats.

Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress.

Efficacy of different Cynara scolymus preparations on liver complaints.

Artichoke leaf extract – Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts.

Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes.

Polyphenols from artichoke heads (Cynara cardunculus (L.) subsp. scolymus Hayek): in vitro bio-accessibility, intestinal uptake and bioavailability.

Peppermint oil

Peppermint oil.

A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia.

Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia.

Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled double-blind equivalence study.

Physical and antimicrobial properties of peppermint oil nanoemulsions.

Peppermint oil decreases the production of virulence-associated exoproteins by Staphylococcus aureus.

The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report.

Artemisia extract

Antimicrobial, antioxidative, and insect repellent effects of Artemisia absinthium essential oil.

Antimicrobial Activity of Artemisia absinthium Against Surgical Wounds Infected by Staphylococcus aureus in a Rat Model.

Volatile composition and antimicrobial activity of the essential oil of Artemisia absinthium growing in Western Ghats region of North West Karnataka, India.

Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria.

Antibacterial activity of some Artemisia species extract.

Screening of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils.

Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France.

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Resveratrol, in its natural combination in whole grape, for health promotion and disease management.

The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials.

Inhibitory effects of resveratrol on platelet activation induced by thromboxane a(2) receptor agonist in human platelets.

Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunction.

Grapes, wines, resveratrol, and heart health.

eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries.

Vasoprotective endothelial effects of a standardized grape product in humans.

Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease.

Cardioprotection with grapes.

Potential health benefits from the flavonoids in grape products on vascular disease.

Green Tea

Association of green tea consumption with risk of coronary heart disease in Chinese population.

Tea and Health: Studies in Humans.

The antioxidant effects of green tea reduces blood pressure and sympathoexcitation in an experimental model of hypertension.

Green tea consumption is associated with reduced incident CHD and improved CHD-related biomarkers in the Dongfeng-Tongji cohort.

Green tea catechins: defensive role in cardiovascular disorders.

Green tea and heart health.

Green tea reverses endothelial dysfunction in healthy smokers.

Prevention of coronary heart disease and cancer by tea, a review.

Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation.


Direct effects of Vaccinium myrtillus L. fruit extracts on rat heart mitochondrial functions.

Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia-reperfusion injury: beyond concentration-dependent antioxidant activity.

Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells.

Effects of Vaccinium Myrtillus anthocyanosides on arterial vasomotion.

Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity.


Tomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways.

Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study.

Lycopene, tomatoes, and coronary heart disease.

Lycopene and human health.

Lycopene, tomatoes, and the prevention of coronary heart disease.

Role of antioxidant lycopene in cancer and heart disease.


Hypotensive action of coumarin glycosides from Daucus carota.

Effect of carrot intake on cholesterol metabolism and on antioxidant status in cholesterol-fed rat.

Colours of fruit and vegetables and 10-year incidence of CHD.

Colors of Fruit and Vegetables and 10-Year Incidence of Stroke.



Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.S. women.

Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats.

Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo.


Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease.

Antiperoxidative, antithyroidal, antihyperglycemic and cardioprotective role of Citrus sinensis peel extract in male mice.

Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.


Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat.

Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed.


A review of the use of bromelain in cardiovascular diseases.

Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium.

Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients.


The potential impact of strawberry on human health.

Promising Health Benefits of the Strawberry: A Focus on Clinical Studies.

Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.

Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt.

Anti-thrombotic effect of strawberries.

Potential impact of strawberries on human health: a review of the science.


Apples in the American diet.

Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice.

Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-?B Pathway.

Apples and cardiovascular health–is the gut microbiota a core consideration?

Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial.

Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K+ channels.

Regulation of vascular endothelial function by procyanidin-rich foods and beverages.

Apple procyanidins induced vascular relaxation in isolated rat aorta through NO/cGMP pathway in combination with hyperpolarization by multiple K+ channel activations.

Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells.


Beneficial effects of apricot-feeding on myocardial ischemia-reperfusion injury in rats.

Mumefural, citric acid derivative improving blood fluidity from fruit-juice concentrate of Japanese apricot (Prunus mume Sieb. et Zucc).

Age-related variations in flavonoid intake and sources in the Australian population.

Prunus Armeniaca (Apricot): An Overview.

Insights into research on phytochemistry and biological activities of Prunus armeniaca L. (apricot).


Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro.

Montmorency Tart cherries (Prunus cerasus L.) modulate vascular function acutely, in the absence of improvement in cognitive performance.

Effects of Montmorency tart cherry (Prunus Cerasus L.) consumption on vascular function in men with early hypertension.

Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits.


Phenolic compounds in Brassica vegetables.

Dietary broccoli sprouts protect against myocardial oxidative damage and cell death during ischemia-reperfusion.

Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury.

Potential health benefits of broccoli- a chemico-biological overview.

Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid.

The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans.

Sulforaphane inhibits endothelial protein C receptor shedding in vitro and in vivo.

Sulforaphane improves oxidative status without attenuating the inflammatory response or cardiac impairment induced by ischemia-reperfusion in rats.

Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway.

The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease.

Antithrombotic activities of sulforaphane via inhibiting platelet aggregation and FIIa/FXa.

The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease.

Green cabbage

Sulforaphane inhibits endothelial protein C receptor shedding in vitro and in vivo.

Sulforaphane improves oxidative status without attenuating the inflammatory response or cardiac impairment induced by ischemia-reperfusion in rats.

Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway.

The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease.

Antithrombotic activities of sulforaphane via inhibiting platelet aggregation and FIIa/FXa.

The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease.


Evaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. bulb on isoprenaline-induced myocardial injury in Wistar albino rats.

Comparison of the hypotensive and bradycardic activity of ginkgo, garlic, and onion extracts.

Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect.

Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat.

An evaluation of garlic and onion as antithrombotic agents.


Traditional herbs: a remedy for cardiovascular disorders.

Allicin: chemistry and biological properties.

Antioxidant action and therapeutic efficacy of Allium sativum L.

Comparison of the hypotensive and bradycardic activity of ginkgo, garlic, and onion extracts.

Antiplatelet activity of Allium ursinum and Allium sativum.

The effect of Allium sativum on ischemic preconditioning and ischemia reperfusion induced cardiac injury.

Herbs and dietary supplements in the prevention and treatment of cardiovascular disease.

Effect of dietary garlic (Allium Sativum) on the blood pressure in humans–a pilot study.

An evaluation of garlic and onion as antithrombotic agents.

Cardioprotective actions of garlic (Allium sativum).

Black currant

Hypotensive, cardiodepressant, and vasorelaxant activities of black currant (Ribes nigrum ‘Ben Sarek’) juice.

The health benefits of blackcurrants.

Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1.

Anti-inflammatory evaluation of a hydroalcoholic extract of black currant leaves (Ribes nigrum).

Wheat germ

Fermented wheat germ extract (avemar) in the treatment of cardiac remodeling and metabolic symptoms in rats.

Wheat germ supplementation of a low vitamin E diet in rats affords effective antioxidant protection in tissues.

A novel antioxidant peptide derived from wheat germ prevents high glucose-induced oxidative stress in vascular smooth muscle cells in vitro.

Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase C gamma 2 activation by Src family kinases.

Wheat germ agglutinin inhibits thrombin-induced rises in cytosolic free calcium and prostacyclin synthesis by human umbilical vein endothelial cells.


Hydroxytyrosol and potential uses in cardiovascular diseases, cancer, and AIDS.

Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review.

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis.

Oleuropein in olive and its pharmacological effects.

Active components and clinical applications of olive oil.


Phytochemical and therapeutic potential of cucumber.

Cucurbitacins – An insight into medicinal leads from nature.

Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy.


Improvement of Blood Pressure, Glucose Metabolism, and Lipid Profile by the Intake of Powdered Asparagus ( Lú Sŭn) Bottom-stems and Cladophylls.

Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2.

Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms.

Folate: a key to optimizing health and reducing disease risk in the elderly.

Chemical constituents of Asparagus

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Bacopa Monnieri

Bacopa Monnieri, has been used as a brain-booster in traditional Ayurvedic medicine since 600 AD. 

Randomized controlled trial of standardized Bacopa monniera Extract in age-associated memory impairment.

Chronic effects of Brahmi (Bacopa monnieri) on human memory.

Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers.

A Six-Week, Randomized Placebo-Controlled Trial

Bacopa monnieri, commonly known as water hyssop, is an herb often used in Ayurveda.

Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain

Enhancement of basolateral amygdaloid neuronal dendritic arborization

The Emporer’s Mushroom (Lion’s Mane) 

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.

Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.

Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.

High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity

Reishi Mushroom

Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits

Superoxide dismutase activity in the nervous system

Snow Fungus Mushroom

Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits

Superoxide dismutase activity in the nervous system

Ginkgo Biloba

Cognitive improvement in memory-impaired individuals of seniority within 24 weeks.

Can provide relaxation therapy via the brain’s blood vessels.

Contains flavonoids that have been shown to protect brain cells from Alzheimers Disease inducing plaques such as beta-amyloid

Helps protect the neurological systems from oxidation via scavenging free radicals.

Panax Ginseng

Enhances cognitive effects in individuals with Alzheimer’s Disease.

Neurological responses and memory abilities improved significantly within lab mice.